Tandem driven dynamic self-inhibition of acetylcholinesterase.

نویسندگان

  • Yan Zhang
  • Marcus Angelin
  • Rikard Larsson
  • Antonia Albers
  • Adrian Simons
  • Olof Ramström
چکیده

A concept of tandem driven dynamic self-inhibition is demonstrated through dynamic inhibitors of acetylcholinesterase (AChE) using reversible transthiolesterification.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Inhibition Revisited in EFL Learning/Teaching

In the affective sphere of EFL learning especially with regard to teaching/learning situations in Iran, one deterrent element seizes particular attention and that is inhibition self-imposed restraint on or abstinence from learning due to academic and non-academic variables such as culture, gender, psyche, extreme emotions, etc. It is related to language ego permeability hypothesis (LEPH) which ...

متن کامل

Evaluating the antioxidant and acetylcholinesterase inhibitory activities of some plants from Kohgiluyeh va Boyerahmad province, Iran

Background and objectives:Alzheimer’s disease (AD) is a neurodegenerative disorder. Nowadays, many investigations are performed to find new drugs for AD and medicinal plants are considered as one of the most important sources for developing new drugs. According to the role of oxidant agents and acetylcholinesterase enzyme (AChE) in AD, plants with antioxidant and AChE inhibitio...

متن کامل

In vitro kinetics and inhibition of krait snake’s venom acetylcholinesterase by Calligonum polygonoides extract in relation to the treatment of Alzheimer’s disease

Objective(s): The objective of this study was to evaluate pharmacological effect of Calligonum polygonoides against Krait snake’s venom acetylcholinesterase (AChE) and to extent it for the treatment of Alzheimer’s disease. Materials and Methods: Acetylcholinesterase activity was measured using Ellman method with some modification. The kinetic studies of methanolic extract of C. polygonoides aga...

متن کامل

Acetylcholinesterase inhibitory effects of some plants from Rosaceae

Background and objectives: Alzheimer's disease (AD) is an age dependent disorder. AD is associated with decrease of brain acetylcholine level. Nowadays, one of the methods for progression inhibition of AD is using acetylcholinesterase inhibitors. Rosaceae is a large plant family. Different biological effects of some species of this family have been reported. The aim of the present study was to ...

متن کامل

ENZYME INHIBITION BY HERBAL MOLLUSCICIDES IN THE NERVOUS TISSUE OF THE SNAIL LYMNAEA ACUMINATA

The effect of Annona squamosa, Lawsonia inermis and their combination with other herbal molluscicides were studied on different enzyme activity in the nervous tissue of Lymnaea acuminata. Twenty-Four hour in vivo exposure to 40% and 80% of 24 h LC50 of plant derived molluscicides and their combination with other molluscicides such as Cedrus deodara, Azadirachta indica oil, Allium sativum, Polia...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 46 44  شماره 

صفحات  -

تاریخ انتشار 2010